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  1. 医学・看護学
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Final Results of a Multicenter Prospective Study of Stereotactic Body Radiation Therapy for Previously Untreated Solitary Primary Hepatocellular Carcinoma(The STRSPH Study)

http://hdl.handle.net/10126/0002000437
http://hdl.handle.net/10126/0002000437
87efacf2-2b54-4b5d-a165-82ebc1d2292d
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International International Journal of Radiation Oncology-Biology -Physics_121_4_942.pdf (517 KB)
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Item type 学術雑誌論文 / Journal Article(1)
公開日 2025-03-03
タイトル
タイトル Final Results of a Multicenter Prospective Study of Stereotactic Body Radiation Therapy for Previously Untreated Solitary Primary Hepatocellular Carcinoma(The STRSPH Study)
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
著者 Naoko, Sanuki

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en Naoko, Sanuki

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Tomoki, Kimura

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en Tomoki, Kimura

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Atsuya, Takeda

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en Atsuya, Takeda

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Keisuke, Ariyoshi

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en Keisuke, Ariyoshi

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Shunsuke, Oyamada

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en Shunsuke, Oyamada

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Takuhiro, Yamaguchi

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en Takuhiro, Yamaguchi

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Yuichiro, Tsurugai

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en Yuichiro, Tsurugai

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Yoshiko, Doi

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en Yoshiko, Doi

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Masaki, Kokubo

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en Masaki, Kokubo

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Toshiyuki, Imagumbai

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en Toshiyuki, Imagumbai

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Norio, Katoh

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en Norio, Katoh

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Takahisa, Eriguchi

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en Takahisa, Eriguchi

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Satoshi, Ishikura

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抄録
内容記述タイプ Abstract
内容記述 Purpose: To report final results of a prospective study of stereotactic body radiation therapy (SBRT) in patients with previously untreated solitary primary hepatocellular carcinoma (HCC).
Methods and Materials: This prospective, single-arm, multicenter phase 2 trial recruited patients with HCC who were unsuitable for, or refused, surgery and radiofrequency ablation, with 3-year overall survival rates as the primary endpoint and survival outcomes and adverse events as secondary endpoints. The prescribed SBRT dose was 40 Gy in 5 fractions. The final data were analyzed in November 2022.
Results: Between 2014 and 2018, 36 patients (median age, 73.5 years) were registered; enrollment was closed before full recruitment due to slow accrual. Overall, 34 patients were analyzed for efficacy evaluation after excluding 2 patients. The median tumor size was 2.3 cm. The median follow-up times for all patients and for survivors were 49 and 56 months, respectively. The 3-year overall survival rate was 82% (95% confidence interval, 65%-92%). The 3-year local control rate was 93% (95% confidence interval, 76%-98%). Grade 3 or higher SBRT-related nonlaboratory toxicities were observed in 4 patients (11%). No grade 5 adverse events were observed.
Conclusions: Final results of this phase 2 trial suggest the efficacy and safety of SBRT for newly diagnosed early-stage HCC that is unfit for other local therapies. Although this study was underpowered by the small number of registrations, the excellent results indicate that SBRT may be an alternative option for the management of early-stage HCC.
言語 en
bibliographic_information en : International Journal of Radiation Oncology Biology Physics

巻 121, 号 4, p. 942-950, 発行日 2025-03-15
item_11_source_id_7
収録物識別子タイプ EISSN
収録物識別子 1879-355X
item_11_relation_11
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.ijrobp.2024.10.040
権利
言語 en
権利情報 © 2024 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
出版者
出版者 Elsevier Inc.
言語 en
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