| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-03-25 |
| タイトル |
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タイトル |
Prognostic role of high-sensitivity cardiac troponin T in patients with cardiac sarcoidosis: insights from ILLUMINATE-CS |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
|
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言語 |
en |
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主題Scheme |
Other |
|
主題 |
cardiovascular event |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
high-sensitivity cardiac troponin T |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
sarcoidosis |
| キーワード |
|
|
言語 |
ja |
|
主題Scheme |
Other |
|
主題 |
心血管イベント |
| キーワード |
|
|
言語 |
ja |
|
主題Scheme |
Other |
|
主題 |
高感度心筋トロポニンT |
| キーワード |
|
|
言語 |
ja |
|
主題Scheme |
Other |
|
主題 |
サルコイドーシス |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
Yuichi,Baba
Toru,Kubo
Takeru,Nabeta
Yuya,Matsue
Takeshi,Kitai
Yoshihisa,Naruse
Tatsunori,Taniguchi
Hidekazu,Tanaka
Takahiro,Okumura
Kenji,Yoshioka
Hiroaki,Kitaoka
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Aims The prognostic role of high-sensitivity cardiac troponin T (hscTnT) as a biomarker in patients with cardiac sarcoidosis(CS) has yet to be fully determined, especially when compared with B-type
natriuretic peptide (BNP).Methods and Results In this post-hoc analysis of the ILLUMINATE-CS (ILLUstration of the Management and prognosIs of JapaNese pATiEnts with Cardiac Sarcoidosis), which is a multicentre retrospective observational study, we analysed 103 patients (62.2 ± 10.9 years old, 31.1% male) diagnosed as CS and with available data for hs-cTnT measured at the time of diagnosis. The primary outcome was the combined outcomes of all-cause death, fatal ventricular arrhythmia events and heart failure hospitalization. During a median follow-up period of 2.6 (inter-quartile range, 1.6–5.7) years, 24 primary outcomes were observed. Patients with a high hs-cTnT level, defined as a level above the median value (>0.016 ng/mL), were associated with a higher incidence of adverse events than those with a low hs-cTnT level (log-rank, P = 0.017). In Cox regression analysis, a
high log-transformed hs-cTnT level and a high log-transformed BNP level were significant risk factors for primary outcome [hazard ratio (HR), 4.368 (95% confidence interval, CI, 1.032–18.480), P = 0.045. and HR, 3.127 (95% CI, 1.029–9.499), P = 0.044, respectively]. Patients with both high hs-cTnT and high BNP (>140 pg/mL: above the median value) levels had a 3.49 (95% CI, 1.23–9.88)-fold increased risk of the primary outcome compared with patients with both low hs-cTnT and low BNP levels.Conclusions In patients with CS, a high hs-cTnT level is a useful predictor of adverse events, and combined measurement of hs-cTnT and BNP further improves the prognostic value. |
|
言語 |
en |
| bibliographic_information |
en : ESC Heart Failure
巻 12,
号 2,
p. 869-878,
発行日 2025-03-17
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| item_11_source_id_7 |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
2055-5822 |
| item_11_relation_11 |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1002/ehf2.15058 |
| 権利 |
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|
言語 |
en |
|
権利情報 |
© 2024 The Author(s). ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
| 出版タイプ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 出版者 |
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出版者 |
John Wiley and Sons Inc |
|
言語 |
en |
ESC Heart Failure_12_2_869.pdf (899 KB)
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